Hydrochloric Acid → HCID 23451800, 화합물

HRID 1277827노트

반응식

HRID 1277827 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:18][C:19](=[O:23])OCC)[CH:5]=[C:6]([Cl:17])[C:7]=1[O:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Cl:16])[CH:10]=1.Cl>O>[CH3:19][N:18]1[CH:4]=[CH:3][N:18]([C:4]2[CH:5]=[C:6]([Cl:17])[C:7]([O:8][C:9]3[CH:10]=[C:11]([Cl:16])[CH:12]=[C:13]([Cl:15])[CH:14]=3)=[C:2]([Cl:1])[CH:3]=2)[C:19]1=[O:23]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 54304496Ethyl [3,5-dichloro-4-(3,5-dichlorophenoxy)phenyl]carbamate

생성물 1

HCID 23451800HCID 23451800, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Ethyl [3,5-dichloro-4-(3,5-dichlorophenoxy)phenyl]carbamate (0.02 mole), water (30 ml) and concentrated hydrochloric acid (3 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer and condenser. The mixture is refluxed for a period of about 30 minutes and then cooled and extracted with ethyl acetate. The extract is washed with dilute aqueous sodium bicarbonate, with two portions of water and is then dried. The ethyl acetate is removed by mild warming under reduced pressure to yield the desired product 1-methyl-3-[3,5-dichloro-4-(3,5-dichlorophenoxy) phenyl]-4-imidazolin-2-one.

후처리

  1. customfitted with a mechanical stirrer
  2. temperatureThe mixture is refluxed for a period of about 30 minutes
  3. temperaturecooled
  4. extractionextracted with ethyl acetate
  5. washThe extract is washed with dilute aqueous sodium bicarbonate, with two portions of water
  6. customis then dried
  7. customThe ethyl acetate is removed
  8. temperatureby mild warming under reduced pressure

출처 및 근거

ORD 기록
ord-28393d8686f44ee0afa8517c0165eadf
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04279637

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