3-(Methylamino)-1-benzoxepin-5(2H)-one → HCID 13446113, 화합물

HRID 1277930노트

반응식

HRID 1277930 반응식
[CH3:1][NH:2][C:3]1[CH2:4][O:5][C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8](=[O:10])[CH:9]=1.[H][H]>[Ni].C(O)C>[CH3:1][NH:2][CH:3]1[CH2:9][CH:8]([OH:10])[C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[O:5][CH2:4]1

참가 물질

5

반응물 2

HCID 134460473-(Methylamino)-1-benzoxepin-5(2H)-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 13446113HCID 13446113, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

18.8 g (0.1 mole) 3-methylamino-1-benzoxepin-5(2H)-one is stirred with 40 g Raney Nickel in 400 ml ethanol for five hours at an hydrogen pressure of 55 bar. Subsequently, the catalyst is filtered out, the solvent is distilled off and one obtains 7.7 g (40% of the theoretical yield) racemic-2,3,4,5-tetrahydro-3-methylamino-1-benzoxepin-5-ol as an oil. The compound can be further separated as described earlier and further identified.

후처리

  1. filtrationSubsequently, the catalyst is filtered out
  2. distillationthe solvent is distilled off
  3. customone obtains 7.7 g (40% of the

출처 및 근거

ORD 기록
ord-b943c0d410744239aaebae8c2953c235
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04279904

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