Dimethylformamide → HCID 20492177, 화합물

HRID 1277992노트

반응식

HRID 1277992 반응식
P(Cl)(Cl)(Cl)=O.[O:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[CH2:11][S:12][CH2:13][CH2:14][N:15]1[C:23](=[O:24])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]1=[O:25].CN(C)[CH:28]=[O:29]>>[CH:28]([C:10]1[O:6][C:7]([CH2:11][S:12][CH2:13][CH2:14][N:15]2[C:23](=[O:24])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:16]2=[O:25])=[CH:8][CH:9]=1)=[O:29]

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 132542762-(2-{[(Furan-2-yl)methyl]sulfanyl}ethyl)-1H-isoindole-1,3(2H)-dione

생성물 1

HCID 20492177HCID 20492177, 화합물

반응 조건

온도
0 °C

실험 절차

Phosphorus oxychloride (B 6.4 g) was added to a stirred solution of 2-[2-[(2-furanylmethyl)thio]ethyl]-1H-isoindole-1,3(2H)-dione (6.0 g) in dry dimethylformamide. After stirring for 2 hr at 0° C. and at room temperature for 12 hr, the mixture was poured into stirred ice-cold water (500 ml). The precipitated solid was collected and crystallised from propan-2-ol yielding the title compound as brown micro-needles (5.6 g) m.p. 77°-79°.

후처리

  1. additionthe mixture was poured
  2. customThe precipitated solid was collected
  3. customcrystallised from propan-2-ol yielding the title compound as brown micro-needles (5.6 g) m.p. 77°-79°

출처 및 근거

ORD 기록
ord-26c426e14cc943a28880a63972d6de69
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04279911

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