Sodium Hydroxide → 2-(4-Bromobenzyl)-1-methylpyrrolidine
반응식
[Br:1]Br.[CH2:3]([CH:10]1[CH2:14][CH2:13][CH2:12][N:11]1[CH3:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[Na+]>[Fe]>[Br:1][C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH:10]2[CH2:14][CH2:13][CH2:12][N:11]2[CH3:15])=[CH:5][CH:6]=1참가 물질
5
실험 절차
Add 11.4 moles of bromine at room temperature to 2 g of 2-benzyl-1-methylpyrrolidine and 50 mg of iron powder. Allow the resulting mixture to stand for 2 hours before rendering it alkaline 1 N sodium hydroxide solution. Extract the base with diethyl ether. Distil the ether extract to obtain the title compound as almost-colorless liquid of b.p. 72° at 0.001 mm of Hg.
후처리
- extractionExtract the base with diethyl ether
- customDistil the ether
- extractionextract
출처 및 근거
- ORD 기록
- ord-ae3e686b01884283883d52e184233057
- 출처 데이터셋
- uspto-grants-1981_07
- 특허 번호
- US04279918
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