Hydroxyamine hydrochloride → 7-(3-Pyridyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

HRID 1278203노트

반응식

HRID 1278203 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH:16]=O)=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.Cl.[NH2:19]O>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]#[N:19])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 21163078HCID 21163078, 화합물

생성물 1

HCID 112183037-(3-Pyridyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 0.01 mole of 7-(3-pyridyl)pyrazolo-[1,5-a]pyrimidine-3-carboxaldehyde and 0.011 mole of hydroxylamine hydrochloride in 25 ml. of ethanol is heated on a steam bath for 3 hours. The solvent is removed and to the residue is added 25 ml. of acetic anhydride. The mixture is heated at reflux temperature for 6 hours and the solvent is removed in vacuo. The residue is partitioned between dichloromethane and sodium bicarbonate solution and the organic layer is separated, dried over magnesium sulfate, and the solvent removed to give the product of the example, m.p. 258°-260° C.

후처리

  1. customThe solvent is removed and to the residue
  2. additionis added 25 ml
  3. temperatureThe mixture is heated
  4. temperatureat reflux temperature for 6 hours
  5. customthe solvent is removed in vacuo
  6. customThe residue is partitioned between dichloromethane and sodium bicarbonate solution
  7. customthe organic layer is separated
  8. dry with materialdried over magnesium sulfate
  9. customthe solvent removed
  10. customto give the product of the example, m.p. 258°-260° C.

출처 및 근거

ORD 기록
ord-6f5245655a8544df90f812649e2d2e9b
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281000

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