Sodium borohydride → HCID 21163070, 화합물

HRID 1278211노트

반응식

HRID 1278211 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH:16]=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[BH4-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH2:16][OH:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 21163078HCID 21163078, 화합물

생성물 1

HCID 21163070HCID 21163070, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2.0 g. of 7-(3-pyridyl)pyrazolo[1,5-a]-pyrimidine-3-carboxaldehyde and 0.35 g. of sodium borohydride in 100 ml. of methanol is stirred for 16 hours. The mixture is concentrated to dryness in vacuo and dichloromethane is added. The solution is washed with saturated sodium bicarbonate and passed through a column of hydrous magnesium silicate. The eluent is concentrated and diluted with hexane to give the product of the example.

후처리

  1. additionA mixture of 2.0 g
  2. concentrationThe mixture is concentrated to dryness in vacuo and dichloromethane
  3. additionis added
  4. washThe solution is washed with saturated sodium bicarbonate
  5. concentrationThe eluent is concentrated
  6. additiondiluted with hexane
  7. customto give the product of the example

출처 및 근거

ORD 기록
ord-d8dab2706e6a4c42ad1893aae81e8fd3
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281000

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