N-bromobutanimide → HCID 12766251, 화합물

HRID 1278214노트

반응식

HRID 1278214 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][CH:15]=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[Br:16]N1C(=O)CCC1=O>ClCCl>[Br:16][C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[CH:8][CH:9]=[N:10][C:11]=12

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 11206374HCID 11206374, 화합물

생성물 1

HCID 12766251HCID 12766251, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 1.96 g. of 7-(3-pyridyl)pyrazolo[1,5-a]-pyrimidine and 1.97 g. of N-bromosuccinimide in 100 ml. of dichloromethane is heated on a steam bath for 15 minutes. The mixture is poured into ice cold 2.5 N sodium hydroxide. The organic layer is separated and dried then is passed through a column of hydrous magnesium silicate. The column is washed with dichloromethane and the eluent is concentrated and diluted with hexane to give 1.8 g. of the product of the example, m.p. 243°-244° C.

후처리

  1. additionA mixture of 1.96 g
  2. customThe organic layer is separated
  3. customdried
  4. washThe column is washed with dichloromethane
  5. concentrationthe eluent is concentrated
  6. additiondiluted with hexane
  7. customto give 1.8 g

출처 및 근거

ORD 기록
ord-4c3bbabffed84782b30cb09ae69a4eaf
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281000

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