Hydrochloric Acid → HCID 21163085, 화합물

HRID 1278220노트

반응식

HRID 1278220 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH2:16][OH:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.Cl.[CH3:19]O>>[CH3:19][O:17][CH2:16][C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[CH:8][CH:9]=[N:10][C:11]=12

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887Methanol2회HCID 21163070HCID 21163070, 화합물

생성물 1

HCID 21163085HCID 21163085, 화합물

실험 절차

To a mixture of 0.01 mole of 7-(3-pyridyl)pyrazolo-[1,5-a]pyrimidine-3-methanol in 50 ml. of methanol is added anhydrous hydrochloric acid in 10 ml. of methanol. The mixture is heated on a steam bath for 3 hours and the solvent removed. The residue is partitioned between dichloromethane and aqueous sodium bicarbonate. The dichloromethane solution is dried over magnesium sulfate, concentrated and diluted with hexane to give the product of the example.

후처리

  1. temperatureThe mixture is heated on a steam bath for 3 hours
  2. customthe solvent removed
  3. customThe residue is partitioned between dichloromethane and aqueous sodium bicarbonate
  4. dry with materialThe dichloromethane solution is dried over magnesium sulfate
  5. concentrationconcentrated
  6. additiondiluted with hexane
  7. customto give the product of the example

출처 및 근거

ORD 기록
ord-f5620bc89ecd4c4ab9827a403433e477
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281000

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