Sodium Hydroxide → 4,4'-((4-((3-(4-Morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine

HRID 1278338노트

반응식

HRID 1278338 반응식
CC1C=CC(S(O)(=O)=O)=CC=1.CC1C=CC(S(O)(=O)=O)=CC=1.Cl[C:24]1[CH:29]=[CH:28][C:27]([S:30]([CH2:33][CH2:34][CH2:35][N:36]2[CH2:41][CH2:40][O:39][CH2:38][CH2:37]2)(=[O:32])=[O:31])=[CH:26][C:25]=1[S:42]([CH2:45][CH2:46][CH2:47][N:48]1[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1)(=[O:44])=[O:43].Cl.[N:55]1([CH2:61][CH2:62][CH2:63][S:64]C(=N)N)[CH2:60][CH2:59][O:58][CH2:57][CH2:56]1.[OH-].[Na+]>O>[N:55]1([CH2:61][CH2:62][CH2:63][S:64][C:24]2[CH:29]=[CH:28][C:27]([S:30]([CH2:33][CH2:34][CH2:35][N:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)(=[O:32])=[O:31])=[CH:26][C:25]=2[S:42]([CH2:45][CH2:46][CH2:47][N:48]2[CH2:53][CH2:52][O:51][CH2:50][CH2:49]2)(=[O:44])=[O:43])[CH2:60][CH2:59][O:58][CH2:57][CH2:56]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 21163758HCID 21163758, 화합물HCID 21163760HCID 21163760, 화합물

생성물 1

HCID 211637644,4'-((4-((3-(4-Morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 5.0 g (0.0060 mole) of 4,4'-((4-chloro-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine bis(4-methylbenzenesulfonate), 1.4 g (0.0060 mole) of S-(3-(4-morpholinyl)propyl)isothiourea hydrochloride and 0.8 g (0.02 mole) of sodium hydroxide in 80 ml of water was heated under reflux with stirring for 3.5 hours, cooled and extracted with methylene chloride. The extract was dried over anhydrous sodium sulfate, and the solvent was removed by evaporation, leaving the product as 4,4'-((4-((3-(4-morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine a yellow, viscous oil.

후처리

  1. temperatureunder reflux
  2. temperaturecooled
  3. extractionextracted with methylene chloride
  4. dry with materialThe extract was dried over anhydrous sodium sulfate
  5. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-b4f67c3d4be24bf081206a6bc760a44c
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281118

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