Benzocaine → Ethyl 4-(15-carbomethoxypentadecylamino)benzoate

HRID 1278387노트

반응식

HRID 1278387 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18].[NH2:21][C:22]1[CH:32]=[CH:31][C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:24][CH:23]=1.CN(C)P(N(C)C)(N(C)C)=O>O>[C:17]([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:21][C:22]1[CH:23]=[CH:24][C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:31][CH:32]=1)([O:19][CH3:20])=[O:18]

참가 물질

5

반응물 3

HCID 2337BenzocaineHCID 12679HexamethylphosphoramideHCID 2736822Methyl 16-bromohexadecanoate

생성물 1

HCID 21163354Ethyl 4-(15-carbomethoxypentadecylamino)benzoate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 21 g. of methyl 16-bromohexadecanoate and 20 g. of ethyl 4-aminobenzoate in 150 ml. of hexamethylphosphoramide is stirred at 120° C. for 20 horus, cooled, diluted with water and filtered. A methylene chloride solution of the solid is dried over anhydrous magnesium sulfate, clarified with activated charcoal, and filtered through silica gel. The filtrate is evaporated and the residue crystallized from acetonitrile to yield ethyl 4-(15-carbomethoxypentadecylamino)benzoate as a white crystalline solid.

후처리

  1. temperaturecooled
  2. filtrationfiltered
  3. dry with materialA methylene chloride solution of the solid is dried over anhydrous magnesium sulfate
  4. filtrationfiltered through silica gel
  5. customThe filtrate is evaporated
  6. customthe residue crystallized from acetonitrile

출처 및 근거

ORD 기록
ord-6ad2399f85db427fafd424bba8cdb596
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04281018

반응 노트

불러오는 중…