Formic Acid → Clarithromycin formate

HRID 1278901

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HRID 1278901 반응식
[CH3:1][CH2:2][C@H:3]1[O:18][C:16](=[O:17])[C@H:15]([CH3:19])[C@@H:14]([O:20][C@@H:21]2[O:26][C@@H:25]([CH3:27])[C@H:24]([OH:28])[C@@:23]([O:30][CH3:31])([CH3:29])[CH2:22]2)[C@H:13]([CH3:32])[C@@H:12]([O:33][C@@H:34]2[O:39][C@H:38]([CH3:40])[CH2:37][C@H:36]([N:41]([CH3:43])[CH3:42])[C@H:35]2[OH:44])[C@@:11]([O:46][CH3:47])([CH3:45])[CH2:10][C@@H:9]([CH3:48])[C:7](=[O:8])[C@H:6]([CH3:49])[C@@H:5]([OH:50])[C@@:4]1([OH:52])[CH3:51].[CH:53]([OH:55])=[O:54]>CC(C)=O>[CH3:1][CH2:2][C@H:3]1[O:18][C:16](=[O:17])[C@H:15]([CH3:19])[C@@H:14]([O:20][C@@H:21]2[O:26][C@@H:25]([CH3:27])[C@H:24]([OH:28])[C@@:23]([O:30][CH3:31])([CH3:29])[CH2:22]2)[C@H:13]([CH3:32])[C@@H:12]([O:33][C@@H:34]2[O:39][C@H:38]([CH3:40])[CH2:37][C@H:36]([N:41]([CH3:42])[CH3:43])[C@H:35]2[OH:44])[C@@:11]([O:46][CH3:47])([CH3:45])[CH2:10][C@@H:9]([CH3:48])[C:7](=[O:8])[C@H:6]([CH3:49])[C@@H:5]([OH:50])[C@@:4]1([OH:52])[CH3:51].[CH:53]([O-:55])=[O:54]

참가 물질

4

반응물 2

HCID 284Formic AcidHCID 84029Clarithromycin

생성물 1

HCID 86758498Clarithromycin formate수율 94%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
0 °C

실험 절차

7.48 g of clarithromycin (purity: 95.4%) was suspended in 70 ml of acetone, and 0.49 ml of formic acid was added thereto and refluxed for 30 minutes. The suspension was cooled to 0° C. and stirred for 2 hours. Then, the resulting crystals were filtered, washed with cold acetone and dried to give 7.42 g of clarithromycin formate (purity: 97.9%, yield: 94%).

후처리

  1. temperaturerefluxed for 30 minutes
  2. filtrationThen, the resulting crystals were filtered
  3. washwashed with cold acetone
  4. customdried

출처 및 근거

ORD 기록
ord-7c081f6e3c264ea492fd1a7e61037172
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06444796B1

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