참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formic Acid | HCID 284 | — |
| 반응물 | Clarithromycin | HCID 84029 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Clarithromycin formate | HCID 86758498 | 94% |
반응 단계
7.48 g of clarithromycin (purity: 95.4%) was suspended in 70 ml of acetone, and 0.49 ml of formic acid was added thereto and refluxed for 30 minutes. The suspension was cooled to 0° C. and stirred for 2 hours. Then, the resulting crystals were filtered, washed with cold acetone and dried to give 7.42 g of clarithromycin formate (purity: 97.9%, yield: 94%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06444796B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_09 |
|---|
| ORD ID | ord-7c081f6e3c264ea492fd1a7e61037172 |
|---|
| 출처 메모 | uspto-grants-2002_09 |
|---|
