Lithium Hydroxide → 2-(Methylthio)pyrimidine-5-carboxylic acid

HRID 1278916노트

반응식

HRID 1278916 반응식
[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([O:11]CC)=[O:10])=[CH:5][N:4]=1.[Li+].[OH-]>O1CCOCC1>[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][N:4]=1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 10442716Ethyl 2-(methylthio)pyrimidine-5-carboxylate

생성물 1

HCID 36317942-(Methylthio)pyrimidine-5-carboxylic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

1 Eq. of 2-methylthio-5-ethoxycarbonylpyrimidine were dissolved in dioxane and, after addition of 2 eq. of 2N LiOH, stirred overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in EtOH. After addition of a stoichiometric amount of ethereal HCl, the solution was again evaporated to dryness. Water which was still present was removed by azeotropic drying with toluene once.

후처리

  1. customThe solvent was then removed under reduced pressure
  2. dissolutionthe residue was dissolved in EtOH
  3. additionAfter addition of a stoichiometric amount of ethereal HCl
  4. customthe solution was again evaporated to dryness
  5. customWater which was still present was removed
  6. dry with materialby azeotropic drying with toluene once

출처 및 근거

ORD 기록
ord-b61b61bb60724619931a278e2bf614e6
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06444817B1

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