Hydrogen Bromide → 4-Methylisoquinolin-7-ol

HRID 127918

반응식

HRID 127918 반응식
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:13])=[CH:8][N:9]=[CH:10]2)=[CH:5][CH:4]=1.Br>>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:13])=[CH:8][N:9]=[CH:10]2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 205232037-Methoxy-4-methylisoquinoline

생성물 1

HCID 205232214-Methylisoquinolin-7-ol

실험 절차

A mixture of 17.3 g. (0.1 mole) of 7-methoxy-4-methylisoquinoline and 100 ml. of 48% hydrobromic acid is refluxed for sixteen hours and evaporated in vacuo. The residue is dissolved in water, neutralized with ammonium hydroxide and filtered to yield 7-hydroxy-4-methylisoquinoline.

후처리

  1. additionA mixture of 17.3 g
  2. customevaporated in vacuo
  3. dissolutionThe residue is dissolved in water
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-948ffba10f3c482688859b302143d3f1
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04258049

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