Ethyl 3-[1-benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-4-nitrobutanoate → 4-[1-Benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-2-pyrrolidone

HRID 1279662노트

반응식

HRID 1279662 반응식
[CH2:1]([O:8][CH:9]1[CH2:12][C:11]([CH:21]([CH2:28][N+:29]([O-])=O)[CH2:22][C:23](OCC)=[O:24])([C:13]([O:15][CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:14])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[CH2:1]([O:8][CH:9]1[CH2:12][C:11]([CH:21]2[CH2:28][NH:29][C:23](=[O:24])[CH2:22]2)([C:13]([O:15][CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:14])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 18427813Ethyl 3-[1-benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-4-nitrobutanoateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 184278094-[1-Benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-2-pyrrolidone

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

A 11.45 g (25.26 mmol) portion of crude ethyl 3-[1-benzyloxy-3-(isoamyloxycarbonyl)cyclobutan-3-yl]-4-nitrobutanoate was dissolved in 200 ml of ethanol to which was subsequently added 10 ml of Raney nickel under an atmosphere of nitrogen. After replacing nitrogen with hydrogen, this was stirred at 50° C. for 5 hours under an atmosphere of hydrogen. After cooling in an ice bath, the reaction solution was filtered through celite and then the solvent was evaporated under a reduced pressure to give 6.51 g (19.5 mmol) of the title compound. The thus obtained compound was used in the following reaction without purification.

후처리

  1. temperatureAfter cooling in an ice bath
  2. filtrationthe reaction solution was filtered through celite
  3. customthe solvent was evaporated under a reduced pressure

출처 및 근거

ORD 기록
ord-2de2fe1682a446bda0105d8fc41ec897
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06448266B1

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