2-Bromo-4-(bromomethyl)benzenemethanol → 2-Bromo-4-(bromomethyl)benzaldehyde

HRID 1280189

반응식

HRID 1280189 반응식
[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][Br:9])[CH:5]=[CH:4][C:3]=1[CH2:10][OH:11]>CCO.CCOC(C)=O.O=[Mn]=O>[Br:9][CH2:8][C:6]1[CH:5]=[CH:4][C:3]([CH:10]=[O:11])=[C:2]([Br:1])[CH:7]=1

참가 물질

4

반응물 1

HCID 120160372-Bromo-4-(bromomethyl)benzenemethanol

생성물 1

HCID 120160382-Bromo-4-(bromomethyl)benzaldehyde수율 80.6%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 21584252Ethanol ethylacetate용매

실험 절차

The compound of Step 2 (8 g, 29 mmol, 1 eq) was dissolved in 10% EtOH/EtOAc (300 ml) and 5 eq of MnO2 (12.4 g, 142 mmol) was added every hour for 6 hours. The mixture was filtered through Celite and the solvent was removed under vacuum to give 6.5 g (80%) of the title compound.

후처리

  1. filtrationThe mixture was filtered through Celite
  2. customthe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-73d50750a02541589a348a788318e6aa
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06448429B1

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