[Cl:1][C:2]1[CH:15]=[C:14]([F:16])[C:13]([NH:17][C:18]([O:20][CH3:21])=[O:19])=[CH:12][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11].C(=O)([O-])[O-].[K+].[K+].Br[CH2:29][C:30]([O:32][CH3:33])=[O:31].O>CN(C)C=O>[Cl:1][C:2]1[CH:15]=[C:14]([F:16])[C:13]([NH:17][C:18]([O:20][CH3:21])=[O:19])=[CH:12][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:29][C:30]([O:32][CH3:33])=[O:31]2-(2-chloro-4-fluoro-5-methoxycarbonylaminophenoxy)phenol [Intermediate compound A9-4] is dissolved in N,N-dimethylformamide, then, potassium carbonate is added, and the mixture is stirred for 1 hour at room temperature. Then, methyl bromoacetate is added at room temperature. The mixture is stirred at 60° C. for 2 hours, poured into water, extracted with ethyl acetate, and the organic layer is washed with dilute hydrochloric acid and water, dried over magnesium sulfate and concentrated to obtain methyl [2-(2-chloro-4-fluoro-5-methoxycarbonylaminophenoxy)phenoxy]acetate [Intermediate compound A9-22].
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