Methyl Isocyanate → 6-bromo-3,4-dihydro-4-hydroxy-3-methyl-4-phenyl-2(1H)-quinazolinone

HRID 128039

반응식

HRID 128039 반응식
[NH2:1][C:2]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH3:17][N:18]=[C:19]=[O:20]>C(Cl)Cl>[Br:16][C:13]1[CH:12]=[C:3]2[C:2](=[CH:15][CH:14]=1)[NH:1][C:19](=[O:20])[N:18]([CH3:17])[C:4]2([OH:5])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 12228Methyl IsocyanateHCID 996772-Amino-5-bromobenzophenone

생성물 1

HCID 234716276-bromo-3,4-dihydro-4-hydroxy-3-methyl-4-phenyl-2(1H)-quinazolinone수율 91.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 14.70 g (0.053 mole) of 2-amino-5-bromobenzophenone and 6.0 g (0.21 mole) of methyl isocyanate in 75 ml of methylene chloride was refluxed for two days and then cooled. The solid portion of the reaction mixture was collected on a filter and washed with methylene chloride to give 16.18 g (90% yield) of 6-bromo-3,4-dihydro-4-hydroxy-3-methyl-4-phenyl-2(1H)-quinazolinone as a white crystalline powder: mp 293°-294° (dec.).

후처리

  1. temperaturecooled
  2. customThe solid portion of the reaction mixture was collected on
  3. filtrationa filter
  4. washwashed with methylene chloride

출처 및 근거

ORD 기록
ord-ec16b9c2a8b145b5bc7dd1ee90612a19
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04258187

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