Hydrochloric Acid → HCID 22747882, 화합물
반응식
[N:1]1([CH2:6][CH:7]2[CH2:11][S:10][C:9]([NH:12]C(=O)OC(C)(C)C)=[N:8]2)[CH:5]=[N:4][CH:3]=[N:2]1.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[N:1]1([CH2:6][CH:7]2[CH2:11][S:10][C:9]([NH2:12])=[N:8]2)[CH:5]=[N:4][CH:3]=[N:2]1참가 물질
4
실험 절차
a solution of 0.3 g of tert-butyl N-[(4RS)-4-(1,2,4-triazol-1-yl-methyl)-4,5-dihydro-2-thiazolyl]carbamate in 10 cm3 of 4N hydrochloric acid in dioxane is stirred at a temperature in the region of 20° C. for 34 hours. The reaction medium is filtered and then washed with 3 times 5 cm3 of diethyl ether and dried in a desiccator. 0.14 g of (4RS)-4-(1,2,4-triazol-1-ylmethyl)-4,5-dihydro-2-thiazolylamine dihydrochloride is obtained in the form of a white foam [mass spectrum: EI m/z=184 MH+ m/z=183 M+ m/z=114 C4H6N2+ M/z=101 C3H5N2S+ base peak m/z=36 HCl DCI m/z=184 MH+].
후처리
- filtrationThe reaction medium is filtered
- washwashed with 3 times 5 cm3 of diethyl ether
- customdried in a desiccator
출처 및 근거
- ORD 기록
- ord-a45428c17cc8478b90142f8f7c708bb6
- 출처 데이터셋
- uspto-grants-2002_09
- 특허 번호
- US06451821B1
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