Allyl bromide → HCID 20507740, 화합물

HRID 128079노트

반응식

HRID 128079 반응식
[N:1]1([C:7]2[N:8]=[C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=[C:10]3[N:11]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[CH2:23](Br)[CH:24]=[CH2:25]>CS(C)=O.[Cl-].[Na+].O>[CH2:25]([N:4]1[CH2:5][CH2:6][N:1]([C:7]2[N:11]=[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=[C:9]3[N:8]=2)[CH2:2][CH2:3]1)[CH:24]=[CH2:23]

참가 물질

6

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 13036368HCID 13036368, 화합물

생성물 1

HCID 20507740HCID 20507740, 화합물수율 72.6%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매2회HCID 57417360Sodium chloride; water용매

실험 절차

A mixture of 2-(1-piperazinyl)cycloheptimidazole (3.15 g, described in Example 2) and potassium carbonate (1.14 g) in dimethyl sulfoxide (10 ml) was stirred for 15 min and a solution of 2-propenyl bromide (1.18 g) in dimethyl sulfoxide was added. The reaction mixture was stirred for 2.5 hr and diluted with brine. The solution was extracted with ethyl acetate and the organic extract was dried and evaporated to give the title compound (1.8 g): mp 108°-111° C.; ir(CHCl3) 1600, 1565 and 1520 cm-1 ; uv max (MeOH) 263(ε29,965), 237(ε25,490) and 362 nm (ε21,620) and nmr(CDCl3)δ 2.6(4H,s), 3.0(2H,d), 4.05(4H,t), 5.15(2H,m), 5.75(1H,m) and 7.65(5H,m).

후처리

  1. stirringThe reaction mixture was stirred for 2.5 hr
  2. extractionThe solution was extracted with ethyl acetate
  3. extractionthe organic extract
  4. customwas dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-6ac9863b3c254022abed5e08ed686052
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04258188

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