Hydrochloric Acid → 5-(3-pyridazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

HRID 12812노트

반응식

HRID 12812 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)[N:2]=1.[ClH:34].O1CCOCC1>CO>[ClH:34].[ClH:34].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:29])[F:30])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)[N:2]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 247593395-(3-pyridazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 686946285-(3-pyridazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-(3-pyridazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione was dissolved in MeOH and treated with 4N HCl in dioxane solution (2 eq). The solvent was evaporated and the residue triturated with diethyl ether to afford 31 mg of the title compound.

후처리

  1. customThe solvent was evaporated
  2. customthe residue triturated with diethyl ether

출처 및 근거

ORD 기록
ord-dab09068b4ba4c12b3f34435fac22fee
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727988B2

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