4-Aminophenol → Phenol, 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-

HRID 128149

반응식

HRID 128149 반응식
[CH:1]1[C:6]([NH2:7])=[CH:5][CH:4]=[C:3]([OH:8])[CH:2]=1.Cl[C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=1[N+:20]([O-:22])=[O:21]>C(O)(C)C>[N+:20]([C:11]1[CH:12]=[C:13]([C:16]([F:17])([F:18])[F:19])[CH:14]=[CH:15][C:10]=1[NH:7][C:6]1[CH:5]=[CH:4][C:3]([OH:8])=[CH:2][CH:1]=1)([O-:22])=[O:21]

참가 물질

4

반응물 2

HCID 4034-AminophenolHCID 84624-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene

생성물 1

HCID 4771887Phenol, 4-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-수율 94.5%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

6.0 g of p-aminophenol was dissolved in 60 ml of isopropyl alcohol. To the solution was added 6.0 g of 4-chloro-3-nitro-benzotrifluoride and the resulting solution was heated under reflux for 12 hours. After the reaction, the solvent was removed by distillation and the residue was dissolved in benzene. The resulting solution was filtered and the solvent was removed from the filtrate by distillation. Thus, 7.5 g of the desired product was obtained.

후처리

  1. temperaturethe resulting solution was heated
  2. temperatureunder reflux for 12 hours
  3. customAfter the reaction
  4. customthe solvent was removed by distillation
  5. dissolutionthe residue was dissolved in benzene
  6. filtrationThe resulting solution was filtered
  7. customthe solvent was removed from the filtrate by distillation

출처 및 근거

ORD 기록
ord-6440437156744dc8be699e3c27fa2396
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259105

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