Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → 2-(p-Fluorobenzoyl)-3-ethoxycrotononitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Triethyl orthoacetate | HCID 66221 | — |
| 반응물 | p-Fluorobenzoylacetonitrile | HCID 2783172 | — |
| 생성물 | 2-(p-Fluorobenzoyl)-3-ethoxycrotononitrile | HCID 70529331 | — |
반응 단계
A solution of 16.3 g. of p-fluorobenzoylacetonitrile and 18.3 ml. of triethyl orthoacetate in 35 ml. of acetic anhydride is heated on a steam bath for 2.5 hours. The solvents are removed in vacuo and the residue is distilled at 165°-167° C./300μ. Upon cooling, this distillate solidifies and is recrystallized from methylene chloride/hexane to give the desired 2-(p-fluorobenzoyl)-3-ethoxycrotononitrile, m.p. 77°/89° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04259256 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-ea48427f139844aca6b6b4feacd5221b |
| 출처 메모 | uspto-grants-1981_03 |