HCID 18422335, 화합물 → Ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate

HRID 1281772

반응식

HRID 1281772 반응식
[F:1][C:2]1[C:22]([F:23])=[CH:21][C:5]([NH:6][C:7]2[S:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]=2[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:4]([N+:24]([O-])=O)[CH:3]=1.[H][H]>[C].[Pd].C(OCC)(=O)C>[NH2:24][C:4]1[CH:3]=[C:2]([F:1])[C:22]([F:23])=[CH:21][C:5]=1[NH:6][C:7]1[S:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[C:8]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

참가 물질

5

반응물 2

HCID 18422335HCID 18422335, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 18422150Ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

In the same manner as in Starting Material Synthesis Example 19 and using ethyl 2-(4,5-difluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate, ethyl acetate, 10% palladium-carbon and hydrogen (60 atm kg/cm2), ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate is obtained.

후처리

  1. customMaterial Synthesis Example 19

출처 및 근거

ORD 기록
ord-47b36bfa83ca42a5b3a0d0fee59e2925
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06455521B1

연결된 노트

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