Potassium Carbonate → 8-fluoro-1,2,3,4-tetrahydro-[1]benzothieno[2,3-b][1,5]benzoxazepin-12(11H)-one
반응식
Br[C:2]1[S:6][C:5]2[CH2:7][CH2:8][CH2:9][CH2:10][C:4]=2[C:3]=1[C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[OH:21])=[O:12].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[F:20][C:17]1[CH:18]=[CH:19][C:14]2[NH:13][C:11](=[O:12])[C:3]3[C:4]4[CH2:10][CH2:9][CH2:8][CH2:7][C:5]=4[S:6][C:2]=3[O:21][C:15]=2[CH:16]=1참가 물질
4
실험 절차
In the same manner as in Example 74 and using 2-bromo-4,5,6,7-tetrahydro-N-(4-fluoro-2-hydroxyphenyl)-benzo[b]thiophene-3-carboxamide, dimethyl sulfoxide and potassium carbonate, 8-fluoro-1,2,3,4-tetrahydro-[1]benzothieno[2,3-b][1,5]benzoxazepin-12(11H)-one is obtained.
출처 및 근거
- ORD 기록
- ord-e6430fdce19246ec81da97f9c012a0fa
- 출처 데이터셋
- uspto-grants-2002_09
- 특허 번호
- US06455521B1
반응 노트
불러오는 중…