Piperazine → 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine

HRID 128205

반응식

HRID 128205 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6]Br.[I-].[Na+].C(=O)([O-])[O-].[K+].[K+].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>CC(CC)=O>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1

참가 물질

6

반응물 4

HCID 4837PiperazineHCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 24522082-(2-Bromoethoxy)-1,3-dimethylbenzene

생성물 1

HCID 234686521-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

To methylethylketone (1 liter) are added 2-(2,6-dimethylphenoxy)-1-bromo-ethane (132 g), sodium iodide (85 g), potassium carbonate (80 g) and piperazine (200 g). The mixture is refluxed for 24 hours, with stirring. After cooling, the mixture is filtered and then washed with 3×300 ml benzene. After evaporation of the benzene, the piperazine derivative is distilled; b.p. 25 mm Hg=190° C.

후처리

  1. temperatureThe mixture is refluxed for 24 hours
  2. temperatureAfter cooling
  3. filtrationthe mixture is filtered
  4. washwashed with 3×300 ml benzene
  5. customAfter evaporation of the benzene
  6. distillationthe piperazine derivative is distilled
  7. customb.p. 25 mm Hg=190° C.

출처 및 근거

ORD 기록
ord-81ef5e212bdb488faab82b396a9fc6ad
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259334

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