Piperazine → 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine
반응식
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6]Br.[I-].[Na+].C(=O)([O-])[O-].[K+].[K+].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>CC(CC)=O>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1참가 물질
6
실험 절차
To methylethylketone (1 liter) are added 2-(2,6-dimethylphenoxy)-1-bromo-ethane (132 g), sodium iodide (85 g), potassium carbonate (80 g) and piperazine (200 g). The mixture is refluxed for 24 hours, with stirring. After cooling, the mixture is filtered and then washed with 3×300 ml benzene. After evaporation of the benzene, the piperazine derivative is distilled; b.p. 25 mm Hg=190° C.
후처리
- temperatureThe mixture is refluxed for 24 hours
- temperatureAfter cooling
- filtrationthe mixture is filtered
- washwashed with 3×300 ml benzene
- customAfter evaporation of the benzene
- distillationthe piperazine derivative is distilled
- customb.p. 25 mm Hg=190° C.
출처 및 근거
- ORD 기록
- ord-81ef5e212bdb488faab82b396a9fc6ad
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04259334
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