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Potassium Iodide → N-(4-(1-(4-(4-fluorophenyl)piperazin-1-yl)-1-methylethyl)phenylmethyl)acetamide dihydrochloride monohydrate

HRID 1282124
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HRID 1282124 반응식
[NH2:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][C:13](=[O:15])[CH3:14])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[Cl:16][CH2:17][CH2:18][N:19]([CH2:27][CH2:28]Cl)[C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CS(C)=O.O>[OH2:15].[ClH:16].[ClH:16].[F:26][C:23]1[CH:24]=[CH:25][C:20]([N:19]2[CH2:27][CH2:28][N:1]([C:2]([C:5]3[CH:10]=[CH:9][C:8]([CH2:11][NH:12][C:13](=[O:15])[CH3:14])=[CH:7][CH:6]=3)([CH3:3])[CH3:4])[CH2:17][CH2:18]2)=[CH:21][CH:22]=1
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HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 30941Aniline, N,N-bis(2-chloroethyl)-p-fluoro-HCID 18423109N-(4-(1-amino-1-methylethyl)phenylmethyl)acetamide

생성물 1

HCID 18423145N-(4-(1-(4-(4-fluorophenyl)piperazin-1-yl)-1-methylethyl)phenylmethyl)acetamide dihydrochloride monohydrate수율 22.6%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

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온도
80 °C

실험 절차

To a solution of N-(4-(1-amino-1-methylethyl)phenylmethyl)-acetamide (1.55 g) and N,N-di(2-chloroethyl)-4-fluoroaniline (1.5 g) in dimethyl sulfoxide (30 ml) were added potassium carbonate (3.12 g) and potassium iodide (2.50 g) and the mixture was stirred at 80° C. for 24 hr. The reaction mixture was poured into water (300 ml) and extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated and the obtained residue was purified by silica gel chromatography (developing solvent; ethyl acetate:hexane=3:1) and treated with 1M hydrochloric acid-ether in ethanol to give the title compound (0.33 g) as white crystals.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated
  5. customthe obtained residue was purified by silica gel chromatography (developing solvent; ethyl acetate:hexane=3:1)
  6. additiontreated with 1M hydrochloric acid-ether in ethanol

출처 및 근거

ORD 기록
ord-e5489caa0e9b47868fbcc60aa2f95bca
출처 데이터셋
uspto-grants-2002_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06455528B1

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