Formaldehyde → HCID 23469001, 화합물

HRID 128239노트

반응식

HRID 128239 반응식
Cl.[CH3:2][NH:3][CH3:4].[CH:5]1([N:11]2[CH:15]=[CH:14][CH:13]=[CH:12]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[CH2:16]=O>C(O)C.O>[CH:5]1([N:11]2[CH:15]=[CH:14][CH:13]=[C:12]2[CH2:2][N:3]([CH3:16])[CH3:4])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]1

참가 물질

6

반응물 3

HCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 138996051-Cyclohexyl-1H-pyrrole

생성물 1

HCID 23469001HCID 23469001, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of dimethylamine hydrochloride (3.76 g) in 40% aqueous formaldehyde (3.5 ml) was added over 30 minutes to a stirred solution of 1-cyclohexylpyrrole in ethanol (25 ml) and the resulting solution was stirred at room temperature for 18 hours. Evaporation of the solution gave a solid which was dissolved in water. The solution was extracted with ether and then basified to pH 9-10 with 1 N sodium hydroxide solution. The resulting oil was extracted with ether (3×50 ml) and the combined ethereal extracts were washed with water and dried (MgSO4). Evaporation of the ether gave an oil which was chromatographed on silica gel. Elution with chloroform gave 1-cyclohexyl-2-(dimethylaminomethyl)pyrrole (5.0 g) as an oil.

후처리

  1. customEvaporation of the solution
  2. customgave a solid which
  3. extractionThe solution was extracted with ether
  4. extractionThe resulting oil was extracted with ether (3×50 ml)
  5. washthe combined ethereal extracts were washed with water
  6. dry with materialdried (MgSO4)
  7. customEvaporation of the ether
  8. customgave an oil which
  9. customwas chromatographed on silica gel
  10. washElution with chloroform

출처 및 근거

ORD 기록
ord-ae019736782a44238c28b9cc71766876
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259345

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