Potassium Carbonate → HCID 54335838, 화합물

HRID 128319

반응식

HRID 128319 반응식
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([CH:6]=[CH:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.C(=O)([O-])[O-].[K+].[K+].CN(C)P(N(C)C)(N(C)C)=O>O>[CH2:24]1[CH2:23][CH2:22][CH2:21][CH:20]([CH2:19][CH2:18][CH2:17][CH2:16][NH:1][C:2]2[CH:3]=[CH:4][C:5]([CH:6]=[CH:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:13][CH:14]=2)[CH2:26][CH2:25]1

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 12679HexamethylphosphoramideHCID 97826Ethyl 3-(4-aminophenyl)acrylateHCID 13131543(4-Bromobutyl)cycloheptane

생성물 1

HCID 54335838HCID 54335838, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of ethyl p-aminocinnamate, 5.9 g. 4-bromobutylcycloheptane and one equivalent of anhydrous powdered potassium carbonate in 50 ml. hexamethylphosphoramide is heated for 20 hours at 60° C. The mixture is then cooled, diluted with water and extracted with ether. The combined ether extracts are dried, filtered and evaporated. Crystallization from acetonitrile provides the title compound as white crystals.

후처리

  1. temperatureThe mixture is then cooled
  2. extractionextracted with ether
  3. dry with materialThe combined ether extracts are dried
  4. filtrationfiltered
  5. customevaporated
  6. customCrystallization from acetonitrile

출처 및 근거

ORD 기록
ord-066ba254822146d2a4d93aa6ba85e614
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259352

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