Acetic Anhydride → Aurone

HRID 1283375

반응식

HRID 1283375 반응식
[O:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:10])[CH2:2]1.C(O[C:15](=O)[CH3:16])(=O)C>>[CH:4]1[CH:5]=[CH:6][C:15](/[CH:16]=[C:2]2/[C:3]([C:4]3[C:9]([O:1]/2)=[CH:8][CH:7]=[CH:6][CH:5]=3)=[O:10])=[CH:2][CH:3]=1

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 23556Coumaranone

생성물 1

HCID 6537099Aurone

반응 조건

온도
100 °C

실험 절차

In which R1 and R2 are as defined in formula I. Thus, as shown above, a 3-coumaranone is reacted with an appropriately substituted benzaldehyde and acetic anhydride by heating at a temperature up to about 100°C. for from 1 to 3 hours. The reaction mixture is treated with ice, extracted with a nonreactive organic solvent such as ether and the product from the extract is heated at reflux for about one hour with a mineral acid, such as hydrochloric acid, an alkanol such as methanol or ethanol, and water. Cooling gives the substituted aurone product.

후처리

  1. additionThe reaction mixture is treated with ice
  2. extractionextracted with a nonreactive organic solvent such as ether
  3. temperaturethe product from the extract is heated
  4. temperatureat reflux for about one hour with a mineral acid, such as hydrochloric acid
  5. temperatureCooling

출처 및 근거

ORD 기록
ord-9d1efaa494c4417a90a2aeaa22adc5de
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03975380

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