5-Bromonicotinic acid → 8-[alpha-(5-Bromonicotinoyloxy)-ethyl]-caffeine

HRID 1283380노트

반응식

HRID 1283380 반응식
Cl[CH:2]([C:4]1[N:13]([CH3:14])[C:12]2[C:11](=[O:15])[N:9]([CH3:10])[C:8](=[O:16])[N:7]([CH3:17])[C:6]=2[N:5]=1)[CH3:3].[Na].[Br:19][C:20]1[CH:21]=[N:22][CH:23]=[C:24]([CH:28]=1)[C:25]([OH:27])=[O:26]>CN(C)C=O>[Br:19][C:20]1[CH:21]=[N:22][CH:23]=[C:24]([CH:28]=1)[C:25]([O:27][CH:2]([C:4]1[N:13]([CH3:14])[C:12]2[C:11](=[O:15])[N:9]([CH3:10])[C:8](=[O:16])[N:7]([CH3:17])[C:6]=2[N:5]=1)[CH3:3])=[O:26]

참가 물질

5

반응물 3

HCID 887075-Bromonicotinic acidHCID 5360545SodiumHCID 681383658-alpha-Chloroethylcaffeine

생성물 1

HCID 215180178-[alpha-(5-Bromonicotinoyloxy)-ethyl]-caffeine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2.87 g of 8-α-chloroethylcaffeine are dissolved in 30 ml of anhydrous dimethylformamide, and then 2.7 g of the sodium salt of dry 5-bromonicotinic acid are added.

출처 및 근거

ORD 기록
ord-0bca3d691b6a46bd80ef682ccbbd7977
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03975389

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