Hydrazine hydrate (1:1) → 6-(3-Chloro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:5]([CH2:7][CH2:8][C:9](O)=[O:10])=O.O.[NH2:18][NH2:19]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[CH2:7][CH2:8][C:9](=[O:10])[NH:18][N:19]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

참가 물질

반응물 2

HCID 24654Hydrazine hydrate (1:1)

HCID 100603124-(3-Chloro-4-methoxyphenyl)-4-oxobutanoic acid

생성물 1

HCID 108238766-(3-Chloro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone수율 84%

실험 절차

This compound was prepared in 84% yield by reaction of 3-(3-chloro-4-methoxybenzoyl)propionic acid with hydrazine hydrate in ethanolic solution at reflux temperature for 5 hours. It had mp 194°-195°C after crystallisation from ethanol.

후처리

temperatureat reflux temperature for 5 hours
customafter crystallisation from ethanol

출처 및 근거

ORD 기록: ord-0b1d343a9ce642808535b831c78997e0
출처 데이터셋: uspto-grants-1976_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US03975388

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