Thiomorpholine 1-oxide → HCID 54325127, 화합물

HRID 1283451

반응식

HRID 1283451 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([NH2:11])[N:5]=[C:4]([S:12][CH3:13])[N:3]=1.[NH:14]1[CH2:19][CH2:18][S:17](=[O:20])[CH2:16][CH2:15]1>CC(C)=O>[NH2:11][C:6]1[N:5]=[C:4]([S:12][CH3:13])[N:3]=[C:2]([N:14]2[CH2:19][CH2:18][S:17](=[O:20])[CH2:16][CH2:15]2)[C:7]=1[N+:8]([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 12600299Thiomorpholine 1-oxideHCID 148930356-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine

생성물 1

HCID 54325127HCID 54325127, 화합물수율 78.2%

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

3.08 gm (0.014 mol) of 4-chloro-6-amino-2-methylthio-5-nitro-pyrimidine were dissolved in 50 ml of acetone, and a solution of 3.2 gm (0.027 mol) of thiomorpholine-1-oxide in 20 ml of acetone was added dropwise at room temperature, while stirring. After stirring the mixture for 1.5 hours more, ice was added to the reaction mixture, and the yellow precipitate formed thereby was suction-filtered off and recrystallized from ethanol. Yield: 78.2% of theory; m.p. 239°-242°C.

후처리

  1. stirringAfter stirring the mixture for 1.5 hours more
  2. additionice was added to the reaction mixture
  3. customthe yellow precipitate formed
  4. filtrationthereby was suction-filtered off
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-f57267dff38147d3a0896ed41a317141
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03975384

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