Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiomorpholine 1-oxide → HCID 54325127, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiomorpholine 1-oxide | HCID 12600299 | — |
| 반응물 | 6-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine | HCID 14893035 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | HCID 54325127 | HCID 54325127 | 78.2% |
반응 단계
3.08 gm (0.014 mol) of 4-chloro-6-amino-2-methylthio-5-nitro-pyrimidine were dissolved in 50 ml of acetone, and a solution of 3.2 gm (0.027 mol) of thiomorpholine-1-oxide in 20 ml of acetone was added dropwise at room temperature, while stirring. After stirring the mixture for 1.5 hours more, ice was added to the reaction mixture, and the yellow precipitate formed thereby was suction-filtered off and recrystallized from ethanol. Yield: 78.2% of theory; m.p. 239°-242°C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03975384 |
| 출처 데이터셋 | uspto-grants-1976_08 |
| ORD ID | ord-f57267dff38147d3a0896ed41a317141 |
| 출처 메모 | uspto-grants-1976_08 |