Diethyl ethylphosphonate → 2,3,5,6-Tetrachloropyridine

HRID 128374노트

반응식

HRID 128374 반응식
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([Cl:9])=[C:4](Cl)[C:3]=1[Cl:11].[Cl-].[NH4+].C(OP(CC)(=O)OCC)C>[Zn]>[Cl:8][C:6]1[C:5]([Cl:9])=[CH:4][C:3]([Cl:11])=[C:2]([Cl:1])[N:7]=1

참가 물질

5

반응물 3

HCID 6534Diethyl ethylphosphonateHCID 16584PentachloropyridineHCID 25517Ammonium Chloride

생성물 1

HCID 169902,3,5,6-Tetrachloropyridine수율 94.1%

시약·촉매·용매 1

HCID 23994Zinc촉매

실험 절차

Using the method described in Example 1, 12.76 g (0.05 mol) of pentachloropyridine is reacted with 4.1 g (0.063 gram atom) of zinc dust and 7.22 g (0.135 mol) of ammonium chloride, the solvent being in this case diethylethanephosphonate instead of dimethylmethanephosphonate. There is obtained 10.2 g (93% of theory) of crude 2,3,5,6-tetrachloropyridine, m.p. 86° to 88° C., which contains, according to gas-chromatographical analysis, 92.7% of 2,3,5,6-tetrachloropyridine, 1.2% of 2,3,5-trichloropyridine, 2.2% of 2,3,6-trichloropyridine and 2.8% of pentachloropyridine.

출처 및 근거

ORD 기록
ord-3afc0861cf6748258194433f3d02927f
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259495

반응 노트

불러오는 중…