Hexylamine → HCID 21516712, 화합물

HRID 1283841

반응식

HRID 1283841 반응식
[N+](C1C=CC(O[C:11](=[O:27])[CH:12]2[CH2:16][CH2:15][CH2:14][N:13]2[C:17]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:18])=CC=1)([O-])=O.[CH2:28]([NH2:34])[CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]>O1CCCC1>[CH2:20]([O:19][C:17]([N:13]1[CH2:14][CH2:15][CH2:16][CH:12]1[C:11]([NH:34][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[O:27])=[O:18])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

4

반응물 2

HCID 8102HexylamineHCID 1029701-Benzyl 2-(4-nitrophenyl) pyrrolidine-1,2-dicarboxylate

생성물 1

HCID 21516712HCID 21516712, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 25.9 g. (0.07 mol.) of N-carbobenzoxy-DL-proline p-nitrophenyl ester in 250 ml. of dry tetrahydrofuran is added 14.1 g. (0.140 mol.) of n-hexylamine in 50 ml. of tetrahydrofuran, and the resulting solution is left overnight at room temperature. The solvent is removed in vacuo, the residue is diluted with ether, and this solution is then washed thoroughly with 1 N aqueous sodium hydroxide, water and then dilute hydrochloric acid. On drying the ether solution and concentrating in vacuo, a pale yellow oil comprising 1-[(benzyloxy)carbonyl]-2-[(hexylamino)carbonyl]pyrrolidine is obtained.

후처리

  1. customThe solvent is removed in vacuo
  2. additionthe residue is diluted with ether
  3. washthis solution is then washed thoroughly with 1 N aqueous sodium hydroxide, water
  4. dry with materialOn drying the ether solution
  5. concentrationconcentrating in vacuo

출처 및 근거

ORD 기록
ord-568e739eac7d4250803e1e8c44164ee0
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03976660

연결된 노트

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