Hydrochloric Acid → 5-Amino-1,3-dihydropyrrol[4,3,2-de]isoquinoline hydrochloride

HRID 1284030노트

반응식

HRID 1284030 반응식
C(O[C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1)C.[OH-].[NH4+:17].[ClH:18].CCOCC>C(O)C>[NH2:17][C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1.[ClH:18].[NH2:17][C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 14923Ammonium HydroxideHCID 215155225-Ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

생성물 2

HCID 215155205-Amino-1,3-dihydropyrrol[4,3,2-de]isoquinoline hydrochlorideHCID 215155215-Amino-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a suspension of 5-ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline (200 mg, 1 mmole), described in Example 5, in ethanol (2 ml), aqueous ammonium hydroxide (25%, 0.5 ml, 1.4 mmole) is added followed by 2.3 N HCl in ethanol (0.5 ml). The mixture is heated at reflux for 0.5 hour, then ether is added and the light green crystalline precipitate collected to give the hydrochloride salt of the title compound, 5-amino-1,3-dihydropyrrol[4,3,2-de]isoquinoline hydrochloride, mp 227° - 228°C.

후처리

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 0.5 hour
  3. customthe light green crystalline precipitate collected

출처 및 근거

ORD 기록
ord-62f82ea11cf54520bb531ed43a5f9e8e
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03978066

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