Hydrazine hydrate (1:1) → 5-Hydrazino-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

HRID 1284032노트

반응식

HRID 1284032 반응식
C(O[C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1)C.O.[NH2:17][NH2:18]>CO>[NH:17]([C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1)[NH2:18]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 215155225-Ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

생성물 1

HCID 30410875-Hydrazino-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

A solution of 5-ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline (10.0 g), described in Example 5, in methanol (100 ml) is combined with a solution of hydrazine hydrate (3 g) in methanol (150 ml). After boiling overnight the mixture is concentrated to half of its original volume and diluted with ether. The resulting precipitate is collected to give the title compound, mp 188° - 189°C, νmaxnujol 3370, 3325, 3150, 1628, 1583, 1540 and 1510 cm-1.

후처리

  1. concentrationthe mixture is concentrated to half of its original volume
  2. additiondiluted with ether
  3. customThe resulting precipitate is collected

출처 및 근거

ORD 기록
ord-b872ab6c2b594ecfb26287bca44f897b
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03978066

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