Ethanol → HCID 12399337, 화합물

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[N:1]1[C:2]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19]CC)=[O:18])=[CH:12][CH:11]=2)=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[N:6][C:5]=12.C(O)C.[OH-].[Na+]>O>[N:1]1[C:2]([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:14][CH:15]=2)=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[N:6][C:5]=12

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실험 절차

A mixture of 6 g of ethyl 4-(imidazo[1,2-a]pyrimidin-2-yl)phenyl-acetate, 30 ml of ethanol, 1.1 g of sodium hydroxide and 5 ml of water is stirred at room temperature for 10 minutes. The crystalline precipitate is filtered off, washed with ethanol, and then dissolved in water. The solution is adjusted to pH 6 by addition of dilute hydrochloric acid. The crystalline precipitate is filtered off and washed with water to give 3.2 g of 4-(imidazo-[1,2-a]pyrimidin-2-yl)phenylacetic acid as colorless crystals melting at 264°-265°C with decomposition.