Dibutyltin oxide → p-Hydroxyphenylpropyloxystearic acid

HRID 1284287

반응식

HRID 1284287 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:13])C(OC)=O)=[CH:4][CH:3]=1.[OH:14][CH:15]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[C:16]([OH:18])=[O:17].[CH2:35]([Sn](=O)CCCC)CCC>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:13][CH2:35][O:14][CH:15]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[C:16]([OH:18])=[O:17])=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 61221Dibutyltin oxideHCID 694172-Hydroxystearic acidHCID 12549710Methyl 2-(4-hydroxyphenyl)propanoate

생성물 1

HCID 68141791p-Hydroxyphenylpropyloxystearic acid

실험 절차

360 parts of methyl p-hydroxyphenylpropionate was reacted with 300 parts of hydroxystearic acid in the presence of 3 parts of dibutyl tin oxide at 150°C. in a nitrogen current for 10 hours. After completion of the reaction, the unreacted excessive methyl p-hydroxyphenylphropionate was distilled at 150°C. under reduced pressure to obtain crude p-hydroxyphenylpropyloxystearic acid. Recrystallization of this crude product from a mixed solvent of methylethylketone and n-hexane gave 350 parts of p-hydroxyphenylpropyloxystearic acid.

후처리

  1. customAfter completion of the reaction
  2. distillationthe unreacted excessive methyl p-hydroxyphenylphropionate was distilled at 150°C. under reduced pressure
  3. customto obtain crude p-hydroxyphenylpropyloxystearic acid
  4. customRecrystallization of this crude product from a mixed solvent of methylethylketone and n-hexane

출처 및 근거

ORD 기록
ord-e546fc9f96874fb8a66239f33ec5f167
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03978153

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