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Water → HCID 13337949, 화합물

HRID 1284529
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HRID 1284529 반응식
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([N+:20]([O-:22])=[O:21])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]4)[CH:12]=3)[C:7](=[O:23])[C:6]([C:24]([OH:26])=[O:25])=[CH:5]2)[CH2:3][CH2:2]1.[C:27]([O:31][CH3:32])(=[O:30])[CH:28]=[CH2:29].O>COCCO.CS(C)=O>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([N+:20]([O-:22])=[O:21])=[C:11]([N:14]4[CH2:19][CH2:18][N:17]([CH2:29][CH2:28][C:27]([O:31][CH3:32])=[O:30])[CH2:16][CH2:15]4)[CH:12]=3)[C:7](=[O:23])[C:6]([C:24]([OH:26])=[O:25])=[CH:5]2)[CH2:2][CH2:3]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 962WaterHCID 7294Methyl AcrylateHCID 4594465HCID 4594465, 화합물

생성물 1

HCID 13337949HCID 13337949, 화합물수율 75.1%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 80192-Methoxyethanol용매

실험 절차

537 mg (0.0015) of 1-cyclopropyl-1,4-dihydro-6-nitro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid in a mixture of 7.5 ml of glycol monomethyl ether and 3 ml of dimethylsulphoxide are heated under reflux with 2 g of methyl acrylate for 8 hours. 10 ml of water are added to the solution and the precipitate is filtered off with suction, washed with methanol and dried. 0.5 g of 1-cyclopropyl-1,4-dihydro-7-[4-(2-methoxycarbonylethyl)-1-piperazinyl]-6-nitro-4-oxo-3-quinolinecarboxylic acid of decomposition point 208° to 211° C. are obtained.

후처리

  1. temperatureare heated
  2. filtrationthe precipitate is filtered off with suction
  3. washwashed with methanol
  4. customdried

출처 및 근거

ORD 기록
ord-663abb4c11ee4e19ae1a3567f913c0f5
출처 데이터셋
uspto-grants-1986_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04563448

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