Hydrazine hydrate (1:1) → 3-(4-Phenylpiperazin-1-yl)propan-1-amine

HRID 1284630

반응식

HRID 1284630 반응식
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][N:16]3C(=O)C4=CC=CC=C4C3=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN>C(O)C>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][CH2:15][NH2:16])[CH2:11][CH2:12]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 64248092-[3-(4-Phenyl-piperazin-1-yl)-propyl]-isoindole-1,3-dione

생성물 1

HCID 2612973-(4-Phenylpiperazin-1-yl)propan-1-amine수율 97.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of N-[3-(4-phenyl-1-piperazinyl)propyl]phthalimide (18.3 g) in ethanol (300 ml) was added 100% hydrazine hydrate (5.3 g). The resulting mixture was refluxed with stirring for 2 hours. The reaction mixture was evaporated under reduced pressure. After the addition of dil aqueous solution of sodium hydroxide to the residue, the mixture was extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and then evaporated under reduced pressure to give 3-(4-phenyl-1-piperazinyl)propylamine (11.2 g).

후처리

  1. temperatureThe resulting mixture was refluxed
  2. customThe reaction mixture was evaporated under reduced pressure
  3. additionAfter the addition of dil aqueous solution of sodium hydroxide to the residue
  4. extractionthe mixture was extracted with chloroform
  5. washThe extract was washed with water
  6. dry with materialdried over magnesium sulfate
  7. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ec7a3e0d59884719a71c632f804aaf86
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04563524

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