Water → HCID 23469776, 화합물

HRID 128469

반응식

HRID 128469 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)=[O:7].[OH-:15].[Na+].C(Cl)(Cl)Cl.[OH2:21]>CC(C)=O>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[CH:13]=[CH:12][C:11]([O:14][C:8]([CH3:13])([CH3:9])[C:6]([OH:21])=[O:15])=[CH:10][CH:9]=1)=[O:7]

참가 물질

6

반응물 4

HCID 962WaterHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 20808Ketone, 2-furyl p-hydroxyphenyl

생성물 1

HCID 23469776HCID 23469776, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

2-Furyl(4-hydroxy-phenyl)ketone (10 g) is dissolved in anhydrous acetone (80 g) and sodium hydroxide (13.2 g) is added thereto; the resulting mixture is stirred for 30 minutes after which anhydrous chloroform (20 g) is added dropwise thereto. On completion of the addition, the mixture is refluxed for 10 hrs. After cooling, the suspension is poured over 2 volumes water and the acetone is evaporated under reduced pressure. The aqueous phase is made acidic, and is then extracted with ethyl ether. The ether phase is neutralized, dried, and the solvent is evaporated off. The resulting solid is recrystallized from benzene, to give 9 g of acid which melts at 127° C. (B)

후처리

  1. additionis added dropwise
  2. additionOn completion of the addition
  3. temperaturethe mixture is refluxed for 10 hrs
  4. temperatureAfter cooling
  5. customthe acetone is evaporated under reduced pressure
  6. extractionis then extracted with ethyl ether
  7. customdried
  8. customthe solvent is evaporated off
  9. customThe resulting solid is recrystallized from benzene

출처 및 근거

ORD 기록
ord-1e31f9fe3cb7497489d1fc43d7b7487d
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259509

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