Monobenzone → 4-[4-(Trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether

HRID 128494

반응식

HRID 128494 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[K+].[F:19][C:20]([F:33])([F:32])[O:21][C:22]1[CH:27]=[CH:26][C:25](Cl)=[C:24]([N+:29]([O-:31])=[O:30])[CH:23]=1>CN(C=O)C>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][C:25]2[CH:26]=[CH:27][C:22]([O:21][C:20]([F:33])([F:19])[F:32])=[CH:23][C:24]=2[N+:29]([O-:31])=[O:30])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 7638MonobenzoneHCID 232972111-Chloro-2-nitro-4-(trifluoromethoxy)benzeneHCID 23664618Potassium methoxide

생성물 1

HCID 234698274-[4-(Trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of 10.01 g. of 4-(benzyloxy)phenol and 3.51 g. (0.05 mole) of potassium methoxide in 75 ml. of DMF is added 12.08 g. (0.05 mole) of 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene. The mixture is heated to complete the reaction. Most of the solvent is removed at reduced pressure and the residue treated with methylene chloride and water. The methylene chloride solution is washed with saturated brine, dried, and the solvent removed, leaving 4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether.

후처리

  1. additionTo a mixture of 10.01 g
  2. temperatureThe mixture is heated
  3. customthe reaction
  4. customMost of the solvent is removed at reduced pressure
  5. additionthe residue treated with methylene chloride and water
  6. washThe methylene chloride solution is washed with saturated brine
  7. customdried
  8. customthe solvent removed

출처 및 근거

ORD 기록
ord-1391ff6e4cd44424a79ed88c9d8f6738
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259532

연결된 노트

불러오는 중…