Hydrochloric Acid → HCID 10037407, 화합물

HRID 1285128노트

반응식

HRID 1285128 반응식
[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1.[ClH:15]>CO>[ClH:15].[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 30625322H-1,4-Thiazin-3(4H)-one, 5-methyl-6-(4-pyridinyl)-

생성물 1

HCID 10037407HCID 10037407, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (5 g) in methanol (500 ml), 12N hydrochloric acid (4 ml) was added dropwise with stirring at room temperature. The reaction mixture was stirred at room temperature for 1 hour and then concentrated in vacuo. Tetrahydrofuran (200 ml) was added and the reaction mixture was stirred at room temperature for 10 minutes, and then filtered. The residue was recrystallized from ethanol to give 4.6 g of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one hydrochloride as pale yellow needles.

후처리

  1. stirringThe reaction mixture was stirred at room temperature for 1 hour
  2. concentrationconcentrated in vacuo
  3. additionTetrahydrofuran (200 ml) was added
  4. stirringthe reaction mixture was stirred at room temperature for 10 minutes
  5. filtrationfiltered
  6. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-c42afcba0ee649bfa06367f523f8df78
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04565813

반응 노트

불러오는 중…