1-Bromo-3-chloropropane → HCID 20197663, 화합물
반응식
[Br:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[OH:10].Br[CH2:12][CH2:13][CH2:14][Cl:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[O:10][CH2:12][CH2:13][CH2:14][Cl:15]참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 2-bromo-4-cyanophenol (3.96 g), 3-bromopropyl chloride (3.46 g), dimethylformamide (20 ml) and anhydrous potassium carbonate (3 g) was heated at 100° C. for 0.5 hour. The inorganic salt was filtered off, and the filtrate was concentrated. The residue was chromatographed on a column of silica gel (90 g), and eluted with a solution of n-hexane-chloroform-acetone (20:10:1) to give 3-(2-bromo-4-cyanophenoxy)propyl chloride as a colorless oil (4.15 g).
후처리
- filtrationThe inorganic salt was filtered off
- concentrationthe filtrate was concentrated
- customThe residue was chromatographed on a column of silica gel (90 g)
- washeluted with a solution of n-hexane-chloroform-acetone (20:10:1)
출처 및 근거
- ORD 기록
- ord-6ed72239da59400fb9b2ae8f49c50590
- 출처 데이터셋
- uspto-grants-1986_01
- 특허 번호
- US04567201
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