Hydrochloric Acid → 2-Methoxy-4-(4-piperidyloxy)benzoic acid

HRID 128583노트

반응식

HRID 128583 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 105458744-((1-(Tert-butoxycarbonyl)piperidin-4-YL)oxy)-2-methoxybenzoic acid

생성물 1

HCID 189141672-Methoxy-4-(4-piperidyloxy)benzoic acid

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid (0.79 g, 2.24 mmol) was dissolved in ethyl acetate (15 ml). The solution was cooled in ice and saturated with HCl gas, then stirred 30 min in the cold. The mixture was evaporated in vacuo and the residue concentrated from ether three times to give 2-methoxy-4-(4-piperidyloxy)benzoic acid.

후처리

  1. customThe mixture was evaporated in vacuo
  2. concentrationthe residue concentrated from ether three times

출처 및 근거

ORD 기록
ord-6b356e6778eb45fba5460e10af218b03
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464788

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