Hydrochloric Acid → HCID 19374875, 화합물

HRID 128690노트

반응식

HRID 128690 반응식
Cl.C([NH:10][C:11](=[S:25])[N:12]([CH:16]([C:18]1[CH:23]=[CH:22][N:21]=[CH:20][C:19]=1[Cl:24])[CH3:17])[CH2:13][CH2:14][CH3:15])(=O)C1C=CC=CC=1>O>[Cl:24][C:19]1[CH:20]=[N:21][CH:22]=[CH:23][C:18]=1[CH:16]([N:12]([CH2:13][CH2:14][CH3:15])[C:11]([NH2:10])=[S:25])[CH3:17]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 19374853HCID 19374853, 화합물

생성물 1

HCID 19374875HCID 19374875, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Add 6 ml of 32% hydrochloric acid to 1.18 g of the compound obtained in Step A. Bring the reaction medium to 80° C. for one hour, then cool and add water. Extract with methylene chloride and discard the organic phase. Alkanilise the aqueous phase with sodium carbonate and extract with methylene chloride. Dry the organic phase and evaporate under vacuum. Purify the residue by chromatography on a silica column, using a mixture of methylene chloride and methanol (98:2 V/V) as eluent.

후처리

  1. temperaturecool
  2. extractionExtract with methylene chloride
  3. extractionAlkanilise the aqueous phase with sodium carbonate and extract with methylene chloride
  4. customDry the organic phase
  5. customevaporate under vacuum
  6. customPurify the residue by chromatography on a silica column
  7. additiona mixture of methylene chloride and methanol (98:2 V/V) as eluent

출처 및 근거

ORD 기록
ord-0a6fbf346934482d880efff9a5832b05
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464847

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