(1,1'-Biphenyl)-4-sulphonyl chloride → N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamide

HRID 128717

반응식

HRID 128717 반응식
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[CH3:11].[C:12]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>>[CH3:11][C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:18]([C:15]1[CH:14]=[CH:13][C:12]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:17][CH:16]=1)(=[O:20])=[O:19]

참가 물질

3

반응물 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 156138784-Methyl-3-(trifluoromethyl)isoxazol-5-amine

생성물 1

HCID 15453174N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamide수율 78%

실험 절차

N-(4-Methyl- 3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamide was prepared in the same manner as described in Example 2b from 5-amino-4-methyl-3-trifluoromethyl-isoxazole and 4-biphenylsulfonyl chloride in 78% yield. Purification was achieved by recrystallization from methanol/water to give a white solid, m.p. 139°-140° C.

후처리

  1. customPurification
  2. customwas achieved by recrystallization from methanol/water
  3. customto give a white solid, m.p. 139°-140° C.

출처 및 근거

ORD 기록
ord-4c73efb1315242f48afe96f8d56d0ff9
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464853

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