1-Isocyanato-4-methoxybenzene → 1-(4-Methoxyphenyl)-3-pentanimidoylurea

HRID 1287375

반응식

HRID 1287375 반응식
[Na].Cl.[C:3]([NH2:9])(=[NH:8])[CH2:4][CH2:5][CH2:6][CH3:7].[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]=[C:19]=[O:20])=[CH:14][CH:13]=1>CC(C)=O>[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:8][C:3](=[NH:9])[CH2:4][CH2:5][CH2:6][CH3:7])=[O:20])=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 794431-Isocyanato-4-methoxybenzeneHCID 5360545SodiumHCID 11615174Pentanimidamide Hydrochloride

생성물 1

HCID 1527470771-(4-Methoxyphenyl)-3-pentanimidoylurea

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

Following a procedure similar to that described in Example 1 but using 3.39 g. sodium in 200 ml. dry acetone, 20 g. valeramidine hydrochloride and 21.9 g. 4-methoxyphenyl isocyanate in 100 ml. dry acetone, there ws obtained after recrystallization from ethyl alcohol 15.5 g. of the hydrochloride of 1-(4-methoxyphenyl)-3-(pentanimidoyl)urea; m.p. 143.5°-145°C.

후처리

  1. customafter recrystallization from ethyl alcohol 15.5 g

출처 및 근거

ORD 기록
ord-2394817f28834cf7b70618df3059b49c
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03984467

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